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By bringing numerous similar lawsuits into a single court, MDLs help reduce duplicative discovery, avoid conflicting rulings across courts, and increase the efficiency of the legal process
N Engl J Med 362(9):774777 Mavrakanas TA, Tsoukas MA, Brophy JM, Sharma A, Gariani K (2023) SGLT-2 inhibitors improve cardiovascular and renal outcomes in patients with CKD: a systematic review and meta-analysis
Patients with active, uncontrolled lupus or RA should optimize disease management first before starting GLP-1
Patients with hypothyroidism still require appropriate thyroid hormone replacement to maintain normal metabolic function
One study used a dose-tapering approach, allowing participants to gradually reduce their GLP-1RA dose and, in some cases, stop the drug entirely without an increase in mean weight
When used with insulin or insulin secretagogues in patients with diabetes, there may be an increased risk of hypoglycemia, requiring dose adjustments of these medications
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